Li Lab @ NUS Cell and Tissue Engineering

Publications

Highlighted

A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts
A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts
Ronghui Li, Jialiang Liang, Su Ni, Ting Zhou, Xiaobing Qing, Huapeng Li, Wenzhi He, Jiekai Chen, Feng Li, Qiang Zhuang, …, Yi Gan, Dajiang Qin, Shipeng Feng, Hong Song, Dongshan Yang, Biliang Zhang, Lingwen Zeng, Liangxue Lai, Miguel Angel Esteban, Duanqing Pei
Cell Stem Cell  ·  01 Jul 2010  ·  doi:10.1016/j.stem.2010.04.014
fibroblast undergo
reprogramming emt met
Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures
Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures
Ronghui Li, Cuiqing Zhong, Yang Yu, Haisong Liu, Masahiro Sakurai, Leqian Yu, Zheying Min, Lei Shi, Yulei Wei, Yuta Takahashi, Hsin-Kai Liao, Jie Qiao, Hongkui Deng, Estrella Nuñez-Delicado, Concepcion Rodriguez Esteban, Jun Wu, Juan Carlos Izpisua Belmonte
Cell  ·  01 Oct 2019  ·  doi:10.1016/j.cell.2019.09.029
differentiation multicellular embryogenesis
Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells
Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells
Haisong Liu, Ronghui Li, Hsin-Kai Liao, Zheying Min, Chao Wang, Yang Yu, Lei Shi, Jiameng Dan, Alberto Hayek, Llanos Martinez Martinez, Estrella Nuñez Delicado, Juan Carlos Izpisua Belmonte
Nature Communications  ·  07 Jun 2021  ·  doi:10.1038/s41467-021-23525-x
differentiation multicellular diabetes
Prevalent mesenchymal drift in aging and disease is reversed by partial reprogramming
Prevalent mesenchymal drift in aging and disease is reversed by partial reprogramming
Jinlong Y. Lu, William B. Tu, Ronghui Li, Mingxi Weng, Bhargav D. Sanketi, Baolei Yuan, Pradeep Reddy, Concepcion Rodriguez Esteban, Juan Carlos Izpisua Belmonte
Cell  ·  01 Oct 2025  ·  doi:10.1016/j.cell.2025.07.031
reprogramming aging

All

2025

Prevalent mesenchymal drift in aging and disease is reversed by partial reprogramming
Prevalent mesenchymal drift in aging and disease is reversed by partial reprogramming
Jinlong Y. Lu, William B. Tu, Ronghui Li, Mingxi Weng, Bhargav D. Sanketi, Baolei Yuan, Pradeep Reddy, Concepcion Rodriguez Esteban, Juan Carlos Izpisua Belmonte
Cell  ·  01 Oct 2025  ·  doi:10.1016/j.cell.2025.07.031
reprogramming aging

2024

In vivo rescue of genetic dilated cardiomyopathy by systemic delivery of nexilin
In vivo rescue of genetic dilated cardiomyopathy by systemic delivery of nexilin
Yanjiao Shao, Canzhao Liu, Hsin-Kai Liao, Ran Zhang, Baolei Yuan, Hanyan Yang, Ronghui Li, Siting Zhu, Xi Fang, Concepcion Rodriguez Esteban, Ju Chen, Juan Carlos Izpisua Belmonte
Genome Biology  ·  23 May 2024  ·  doi:10.1186/s13059-024-03283-x

2022

Towards capturing of totipotency
Towards capturing of totipotency
Cuiqing Zhong, Ronghui Li, Juan Carlos Izpisua Belmonte
Cell Research  ·  05 Jul 2022  ·  doi:10.1038/s41422-022-00686-y
Time matters: Human blastoids resemble the sequence of blastocyst development
Time matters: Human blastoids resemble the sequence of blastocyst development
Ronghui Li, Cuiqing Zhong, Juan Carlos Izpisua Belmonte
Cell  ·  01 Feb 2022  ·  doi:10.1016/j.cell.2022.01.005
Transcriptomic profiling fuels the derivation of stable pig epiblast stem cells
Transcriptomic profiling fuels the derivation of stable pig epiblast stem cells
Cuiqing Zhong, Ronghui Li, Juan Carlos Izpisua Belmonte
Cell Research  ·  12 Jan 2022  ·  doi:10.1038/s41422-021-00609-3

2021

Protocol for the generation of blastocyst-like structures from mouse extended pluripotent stem cells
Protocol for the generation of blastocyst-like structures from mouse extended pluripotent stem cells
Ronghui Li, Juan Carlos Izpisua Belmonte
STAR Protocols  ·  01 Sep 2021  ·  doi:10.1016/j.xpro.2021.100745
Differentiation protocol for generating functional pancreatic β cells from human pluripotent stem cells
Differentiation protocol for generating functional pancreatic β cells from human pluripotent stem cells
Haisong Liu, Ronghui Li, Hsin-Kai Liao, Juan Carlos Izpisua Belmonte
Springer Science and Business Media LLC  ·  08 Jun 2021  ·  doi:10.21203/rs.3.pex-1413/v1
Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells
Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells
Haisong Liu, Ronghui Li, Hsin-Kai Liao, Zheying Min, Chao Wang, Yang Yu, Lei Shi, Jiameng Dan, Alberto Hayek, Llanos Martinez Martinez, Estrella Nuñez Delicado, Juan Carlos Izpisua Belmonte
Nature Communications  ·  07 Jun 2021  ·  doi:10.1038/s41467-021-23525-x
differentiation multicellular diabetes

2019

Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures
Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures
Ronghui Li, Cuiqing Zhong, Yang Yu, Haisong Liu, Masahiro Sakurai, Leqian Yu, Zheying Min, Lei Shi, Yulei Wei, Yuta Takahashi, Hsin-Kai Liao, Jie Qiao, Hongkui Deng, Estrella Nuñez-Delicado, Concepcion Rodriguez Esteban, Jun Wu, Juan Carlos Izpisua Belmonte
Cell  ·  01 Oct 2019  ·  doi:10.1016/j.cell.2019.09.029
differentiation multicellular embryogenesis

2018

Mechanism and consequence of abnormal calcium homeostasis in Rett syndrome astrocytes
Mechanism and consequence of abnormal calcium homeostasis in Rett syndrome astrocytes
Qiping Dong, Qing Liu, Ronghui Li, Anxin Wang, Qian Bu, Kuan Hong Wang, Qiang Chang
eLife  ·  29 Mar 2018  ·  doi:10.7554/eLife.33417

2017

CREB Signaling Is Involved in Rett Syndrome Pathogenesis
CREB Signaling Is Involved in Rett Syndrome Pathogenesis
Qian Bu, Anxin Wang, Hamdi Hamzah, Alex Waldman, Keer Jiang, Qiping Dong, Ronghui Li, Jason Kim, Daniel Turner, Qiang Chang
The Journal of Neuroscience  ·  07 Mar 2017  ·  doi:10.1523/JNEUROSCI.3735-16.2017
CREB Signaling Is Involved in Rett Syndrome Pathogenesis
CREB Signaling Is Involved in Rett Syndrome Pathogenesis
Qian Bu, Anxin Wang, Hamdi Hamzah, Alex Waldman, Keer Jiang, Qiping Dong, Ronghui Li, Jason Kim, Daniel Turner, Qiang Chang
The Journal of Neuroscience  ·  07 Mar 2017  ·  doi:10.1523/jneurosci.3735-16.2017

2016

Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome
Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome
Ronghui Li, Qiping Dong, Xinni Yuan, Xin Zeng, Yu Gao, Cassandra Chiao, Hongda Li, Xinyu Zhao, Sunduz Keles, Zefeng Wang, Qiang Chang
PLOS Genetics  ·  28 Jun 2016  ·  doi:10.1371/journal.pgen.1006129

2014

Mutant astrocytes differentiated from Rett syndrome patients-specific iPSCs have adverse effects on wild-type neurons
Mutant astrocytes differentiated from Rett syndrome patients-specific iPSCs have adverse effects on wild-type neurons
Emily Cunningham Williams, Xiaofen Zhong, Ahmed Mohamed, Ronghui Li, Yan Liu, Qiping Dong, Gene E. Ananiev, Jonathan Chern Choong Mok, Benjamin Ray Lin, Jianfeng Lu, Cassandra Chiao, Rachel Cherney, Hongda Li, Su-Chun Zhang, Qiang Chang
Human Molecular Genetics  ·  12 Jan 2014  ·  doi:10.1093/hmg/ddu008

2010

Towards an Optimized Culture Medium for the Generation of Mouse Induced Pluripotent Stem Cells
Towards an Optimized Culture Medium for the Generation of Mouse Induced Pluripotent Stem Cells
Jiekai Chen, Jing Liu, Qingkai Han, Dajiang Qin, Jianyong Xu, You Chen, Jiaqi Yang, Hong Song, Dongshan Yang, Meixiu Peng, Wenzhi He, Ronghui Li, Hao Wang, Yi Gan, Ke Ding, Lingwen Zeng, Liangxue Lai, Miguel A. Esteban, Duanqing Pei
Journal of Biological Chemistry  ·  01 Oct 2010  ·  10.1074/jbc.M110.139436
Towards an Optimized Culture Medium for the Generation of Mouse Induced Pluripotent Stem Cells
Towards an Optimized Culture Medium for the Generation of Mouse Induced Pluripotent Stem Cells
Jiekai Chen, Jing Liu, Qingkai Han, Dajiang Qin, Jianyong Xu, You Chen, Jiaqi Yang, Hong Song, Dongshan Yang, Meixiu Peng, Wenzhi He, Ronghui Li, Hao Wang, Yi Gan, Ke Ding, Lingwen Zeng, Liangxue Lai, Miguel A. Esteban, Duanqing Pei
Journal of Biological Chemistry  ·  01 Oct 2010  ·  doi:10.1074/jbc.m110.139436
A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts
A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts
Ronghui Li, Jialiang Liang, Su Ni, Ting Zhou, Xiaobing Qing, Huapeng Li, Wenzhi He, Jiekai Chen, Feng Li, Qiang Zhuang, …, Yi Gan, Dajiang Qin, Shipeng Feng, Hong Song, Dongshan Yang, Biliang Zhang, Lingwen Zeng, Liangxue Lai, Miguel Angel Esteban, Duanqing Pei
Cell Stem Cell  ·  01 Jul 2010  ·  doi:10.1016/j.stem.2010.04.014
fibroblast undergo
reprogramming emt met